Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28565083 | 0.83 | HPGD (0.45) | ALDH1A1SMN1; SMN2CYP3A4MAPTPOLB | |
| SCHEMBL2335060 | 0.82 | ALDH1A1 (0.56) | PRMT5WDR77ALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL9699360 | 0.81 | ALDH1A1 (0.49) | PRMT5WDR77ALDH1A1SMN1; SMN2CYP3A4 | |
| SCHEMBL3808783 | 0.80 | NPC1 (0.60) | ALDH1A1SMN1; SMN2MAPTPOLBTDP1 | |
| SCHEMBL4211452 | 0.80 | NPC1 (0.60) | ALDH1A1SMN1; SMN2MAPTPOLBTDP1 | |
| SCHEMBL4211458 | 0.80 | NPC1 (0.60) | ALDH1A1SMN1; SMN2MAPTPOLBTDP1 | |
| SCHEMBL20535670 | 0.80 | TLR4 (0.45) | ALDH1A1SMN1; SMN2MAPTPOLBHPGD | |
| SCHEMBL26162631 | 0.76 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2CYP3A4MAPTPOLB | |
| SCHEMBL11590835 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2CYP3A4TP53TSHR | |
| SCHEMBL26977909 | 0.76 | MAPT (0.47) | ALDH1A1SMN1; SMN2CYP3A4TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112820-A | Vision defects | STERLING DRUG INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5109135-A | 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | STERLING DRUG INC. (US) | 1992-04-28 | — | — | US | disclosed |
| US-5066803-A | Chemical intermediates for analgesics | STERLING DRUG INC. (US) | 1991-11-19 | — | — | US | disclosed |
| WO-1990007505-A1 | 2- AND 3-AMINOMETHYL-6-ARYLCARBONYL-2,3-DIHYDROPYRROLO[1,2,3-de]-1,4-BENZOXAZINES | STERLING DRUG INC. (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4939138-A | 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo(1,2,3-DE)-1,4-benzoxazines | STERLING DRUG INC. (US) | 1990-07-03 | — | — | US | disclosed |