SCHEMBL28565451

SCHEMBL28565451

O=CC(=O)c1nc2ncccc2[nH]1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NUDT1 P36639 1/20 0.50
KDM4E B2RXH2 2/20 0.49
CYP1A2 P05177 2/20 0.49
MAPT P10636 2/20 0.49
CYP2C9 P11712 2/20 0.49
CYP2C19 P33261 2/20 0.49
DAGLA Q9Y4D2 1/20 0.49
HPSE Q9Y251 2/20 0.47
PDE10A Q9Y233 2/20 0.46
CYP2D6 P10635 1/20 0.46
PDE5A O76074 2/20 0.45
METAP1 P53582 2/20 0.45
METAP2 P50579 1/20 0.45
KMT2A Q03164 1/20 0.45
ALDH1A1 P00352 2/20 0.43
ATM Q13315 1/20 0.43
PRMT5 O14744 1/20 0.42
HPGD P15428 1/20 0.41
AURKA O14965 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27832091 0.82 PDE10A (0.57) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL29623058 0.81 DAGLA (0.56) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL2291563 0.81 DAGLA (0.56) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL30943978 0.79 NUDT1 (0.58) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL853165 0.79 NUDT1 (0.58) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL24112427 0.79 NUDT1 (0.53) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL2079832 0.78 DAGLA (0.53) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL6246031 0.77 NUDT1 (0.50) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL24740172 0.75 NUDT1 (0.49) NUDT1KDM4ECYP1A2MAPTCYP2C9
SCHEMBL31717984 0.75 KMT2A (0.57) NUDT1KDM4ECYP1A2MAPTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108003156-B Synthesis method of imidazopyridyl 1, 2-ethanedione derivative 辽宁科技大学 2021-04-20 CN claimed
CN-108003156-B Synthesis method of imidazopyridyl 1, 2-ethanedione derivative 辽宁科技大学 2021-04-20 CN disclosed
CN-108003156-B Synthesis method of imidazopyridyl 1, 2-ethanedione derivative 辽宁科技大学 2021-04-20 CN disclosed
CN-108003156-B Synthesis method of imidazopyridyl 1, 2-ethanedione derivative 辽宁科技大学 2021-04-20 CN disclosed