Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 15/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008512 | 0.91 | GPR52 (0.41) | GPR52MAPK14HTR2BBRD4MRGPRX4 | |
| SCHEMBL18567061 | 0.89 | GPR52 (0.44) | GPR52MAPK14HTR2BBRD4HCK | |
| SCHEMBL17008514 | 0.86 | MAPK14 (0.46) | GPR52MAPK14BRD4HCKMAPK12 | |
| SCHEMBL17008486 | 0.83 | MAPK14 (0.44) | GPR52MAPK14MRGPRX4HCKMAPK12 | |
| SCHEMBL28588449 | 0.82 | LRRK2 (0.45) | MAPK14MRGPRX4HCKMAPK12 | |
| SCHEMBL17017553 | 0.82 | MAPK14 (0.44) | GPR52MAPK14BRD4HCKMAPK12 | |
| SCHEMBL28578481 | 0.79 | HCK (0.39) | MAPK14MRGPRX4HCKMAPK12 | |
| SCHEMBL17017129 | 0.79 | MRGPRX4 (0.40) | MAPK14MRGPRX4HCKMAPK12 | |
| SCHEMBL17008525 | 0.78 | MAPK14 (0.42) | GPR52MAPK14MRGPRX4HCKMAPK12 | |
| SCHEMBL31086537 | 0.78 | MAPK14 (0.42) | GPR52MAPK14MRGPRX4HCKMAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264921-A | Pyrazolyl-ureas as kinase inhibitors | 瑞斯比维特有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-106573914-B | Pyrazolyl-ureas as kinase inhibitors | 瑞斯比维特有限公司 | 2021-05-28 | — | — | CN | disclosed |