Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 6/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008500 | 0.88 | LRRK2 (0.46) | LRRK2JAK2JAK1TYK2SRC | |
| SCHEMBL28573504 | 0.86 | HCK (0.38) | LRRK2SRCHCKMAPK12MAPK14 | |
| SCHEMBL31086658 | 0.85 | LRRK2 (0.41) | LRRK2JAK2JAK1TYK2SRC | |
| SCHEMBL17008501 | 0.85 | LRRK2 (0.41) | LRRK2JAK2JAK1TYK2SRC | |
| SCHEMBL28578481 | 0.84 | HCK (0.39) | SRCHCKMAPK12MAPK14NR3C2 | |
| SCHEMBL18567054 | 0.83 | LRRK2 (0.41) | LRRK2JAK2JAK1TYK2SRC | |
| SCHEMBL17017643 | 0.83 | LRRK2 (0.41) | LRRK2JAK2JAK1TYK2SRC | |
| SCHEMBL28566737 | 0.82 | GPR52 (0.40) | HCKMAPK12MAPK14MRGPRX4 | |
| SCHEMBL17008491 | 0.80 | LMNA (0.40) | LRRK2SRCHCKMAPK12MAPK14 | |
| SCHEMBL31086600 | 0.80 | LMNA (0.40) | LRRK2SRCHCKMAPK12MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264921-A | Pyrazolyl-ureas as kinase inhibitors | 瑞斯比维特有限公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-106573914-B | Pyrazolyl-ureas as kinase inhibitors | 瑞斯比维特有限公司 | 2021-05-28 | — | — | CN | disclosed |