Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 5/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439875 | 1.00 | MAP4K4 (0.51) | MAP4K4SYKAURKAPDPK1AURKB | |
| SCHEMBL27796418 | 0.90 | LMNA (0.43) | MAP4K4SYKAURKAPDPK1AURKB | |
| SCHEMBL28605703 | 0.89 | SYK (0.51) | MAP4K4SYKAURKAPDPK1AURKB | |
| SCHEMBL28605705 | 0.89 | SYK (0.51) | MAP4K4SYKAURKAPDPK1AURKB | |
| SCHEMBL4437136 | 0.89 | KDM4E (0.49) | SYKKDM4EALDH1A1LMNAPIM1 | |
| SCHEMBL28566874 | 0.88 | HTT (0.54) | MAP4K4SYKAURKAPDPK1AURKB | |
| SCHEMBL4445734 | 0.87 | MAP4K4 (0.53) | MAP4K4SYKAURKAPDPK1AURKB | |
| SCHEMBL4436879 | 0.86 | MAP4K4 (0.52) | MAP4K4AURKAPDPK1AURKBF10 | |
| SCHEMBL28572991 | 0.85 | MAP4K4 (0.52) | MAP4K4AURKAPDPK1AURKBF10 | |
| SCHEMBL4439169 | 0.85 | MAP4K4 (0.52) | MAP4K4AURKAPDPK1AURKBF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108373476-B | Kinase inhibitor and preparation and application thereof | 成都地奥制药集团有限公司 | 2021-06-01 | — | — | CN | disclosed |