Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfamethoxypyridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfamethoxypyridazine SCHEMBL11026411 | 0.81 | LMNA (0.94) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| Sulfamethoxypyridazine SCHEMBL93617 | 0.80 | LMNA (1.00) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| Sulfamethoxypyridazine SCHEMBL10777132 | 0.80 | LMNA (1.00) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| Sulfamethoxypyridazine SCHEMBL29360723 | 0.80 | LMNA (1.00) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| Sulfamethoxypyridazine SCHEMBL29377020 | 0.80 | LMNA (1.00) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| Sulfamethoxypyridazine SCHEMBL27484423 | 0.79 | LMNA (0.97) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| Sulfamethoxypyridazine SCHEMBL11516439 | 0.79 | LMNA (0.97) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL29471766 | 0.76 | LMNA (0.75) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| SCHEMBL2490831 | 0.76 | LMNA (0.75) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 | |
| Sulfamethoxypyridazine SCHEMBL28086651 | 0.75 | LMNA (0.77) | LMNASMN1; SMN2CYP2C19ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108931599-B | Method for extracting and analyzing sulfonamides by using DPX gun head type dispersed solid phase microextraction column | 无锡微色谱生物科技有限公司 | 2021-06-01 | — | — | CN | disclosed |