SCHEMBL2856783

SCHEMBL2856783

O=CNCCc1ccc(Cl)cc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.51
GPR84 Q9NQS5 1/20 0.50
TAAR1 Q96RJ0 1/20 0.49
HPGD P15428 1/20 0.49
PLA2G1B P04054 1/20 0.47
ATG4B Q9Y4P1 1/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
ALDH1A1 P00352 2/20 0.46
IDO1 P14902 1/20 0.46
HTT P42858 1/20 0.45
PLAAT3 P53816 1/20 0.45
PLAAT5 Q96KN8 1/20 0.45
PLAAT2 Q9NWW9 1/20 0.45
PLAAT4 Q9UL19 1/20 0.45
TP53 P04637 1/20 0.44
MAPK1 P28482 2/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28650574 0.83 TAAR1 (0.55) CNR1GPR84TAAR1HPGDPLA2G1B
SCHEMBL4887074 0.81 HTT (0.51) TAAR1KMT2AMEN1ALDH1A1IDO1
Hydrochloric Acid SCHEMBL28654800 0.81 HTT (0.54) CNR1GPR84TAAR1HPGDPLA2G1B
SCHEMBL585624 0.79 IDO1 (0.50) CNR1GPR84TAAR1HPGDIDO1
SCHEMBL2469837 0.78 TAAR1 (0.58) CNR1GPR84TAAR1IDO1PLAAT3
SCHEMBL28156393 0.77 KMT2A (0.44) CNR1GPR84TAAR1HPGDPLA2G1B
SCHEMBL11621292 0.76 IDO1 (0.65) CNR1GPR84IDO1HTTTP53
SCHEMBL680436 0.76 TAAR1 (0.60) CNR1GPR84TAAR1HPGDKMT2A
SCHEMBL6894441 0.76 CNR1 (0.51) CNR1GPR84TAAR1HPGDKMT2A
SCHEMBL97596 0.75 ACLY (0.47) IDO1MAPK1CYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113292493-A Preparation method of 5, 7-dichloro-1, 2,3, 4-tetrahydroisoquinoline 上海立科化学科技有限公司 2021-08-24 CN claimed
CN-113292493-A Preparation method of 5, 7-dichloro-1, 2,3, 4-tetrahydroisoquinoline 上海立科化学科技有限公司 2021-08-24 CN disclosed
CN-113292493-A Preparation method of 5, 7-dichloro-1, 2,3, 4-tetrahydroisoquinoline 上海立科化学科技有限公司 2021-08-24 CN disclosed
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 EP disclosed
EP-1409468-A2 GUANIDINOBENZAMIDES AS MC4-R AGONISTS CHIRON CORPORATION (US) 2004-04-21 EP disclosed
WO-2002018327-A2 GUANIDINOBENZAMIDES AS MC4-R AGONISTS CHIRON CORPORATION (US) 2002-03-07 WO disclosed
EP-0542867-A4 METHODS OF PREVENTING OR DECREASING TISSUE DAMAGE BY NOVEL ANTIOXIDANTS AND FREE RADICAL SCAVENGERS 1993-07-28 EP disclosed
EP-0542867-A1 METHODS OF PREVENTING OR DECREASING TISSUE DAMAGE BY NOVEL ANTIOXIDANTS AND FREE RADICAL SCAVENGERS GENSIA, INC. (US) 1993-05-26 EP disclosed