Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.37 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2880891 | 0.83 | CNR1 (0.54) | NPC1RAB9AKDM4EMAPTNPSR1 | |
| SCHEMBL2860983 | 0.82 | MAPT (0.49) | NPC1RAB9AKDM4EMAPTNPSR1 | |
| SCHEMBL2858063 | 0.82 | MAPT (0.57) | NPC1RAB9AKDM4EMAPTNPSR1 | |
| SCHEMBL2862263 | 0.82 | MAPT (0.47) | NPC1RAB9AKDM4EMAPTNPSR1 | |
| SCHEMBL2856146 | 0.81 | CNR1 (0.53) | NPC1RAB9AKDM4EMAPTNPSR1 | |
| SCHEMBL2852086 | 0.80 | ITGB3 (0.53) | NPC1RAB9AKDM4EMAPTNPSR1 | |
| SCHEMBL2854478 | 0.80 | ITGB3 (0.46) | NPC1RAB9AMAPTNPSR1TRPV1 | |
| SCHEMBL2852504 | 0.80 | CNR1 (0.56) | NPC1RAB9AKDM4EMAPTNPSR1 | |
| SCHEMBL2850703 | 0.80 | CNR1 (0.56) | NPC1RAB9AMAPTNPSR1ALDH1A1 | |
| SCHEMBL2855728 | 0.80 | CCNC (0.50) | NPC1RAB9AMAPTNPSR1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |