Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30360009 | 0.78 | NPSR1 (0.55) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL23496549 | 0.75 | KMT2A (0.48) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL31020184 | 0.75 | KMT2A (0.48) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL21633710 | 0.73 | KMT2A (0.48) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL28571128 | 0.72 | KMT2A (0.47) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL31020187 | 0.71 | MEN1 (0.46) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL23516703 | 0.71 | MEN1 (0.46) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL31020180 | 0.69 | HTT (0.42) | MAPTNPC1RAB9ANPSR1HPGD | |
| SCHEMBL23931167 | 0.68 | KMT2A (0.55) | MAPTNPC1RAB9ASLC2A1KMT2A | |
| SCHEMBL11790910 | 0.67 | SLC2A1 (0.69) | MAPTNPC1RAB9ANPSR1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112638376-A | Substituted tetrahydrocyclopenta [ c ] pyrroles, substituted dihydropyrrolizines, analogs thereof and methods of use thereof | 爱彼特生物制药公司 | 2021-04-09 | — | — | CN | disclosed |