Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 3/20 | 0.62 |
| ▸ | CYP2E1 | P05181 | 15/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 15/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 15/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 15/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 15/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 14/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 13/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | BRS3 | P32247 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2104819 | 0.91 | MYC (0.52) | MYCCYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL2105865 | 0.85 | MYC (0.51) | MYCCYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL29952097 | 0.84 | MYC (0.48) | MYCRAB9ALMNA | |
| SCHEMBL2857240 | 0.84 | MYC (0.48) | MYCRAB9ALMNA | |
| SCHEMBL2107497 | 0.82 | MYC (0.61) | MYCCYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL2106204 | 0.79 | MYC (0.61) | MYCLMNA | |
| SCHEMBL2100202 | 0.79 | MYC (0.67) | MYCLMNA | |
| SCHEMBL2105385 | 0.78 | MYC (0.58) | MYCLMNA | |
| SCHEMBL2107082 | 0.78 | ALDH1A1 (0.47) | MYCCYP2D6CYP2C9CYP2C19CYP1A2 | |
| SCHEMBL17822478 | 0.77 | MYC (0.69) | MYCCYP2D6CYP2C9CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1746097-B1 | 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them | AVENTIS PHARMA SA (FR) | 2010-01-13 | — | — | EP | disclosed |
| EP-1746097-A1 | 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them | Aventis Pharma S.A. (FR) | 2007-01-24 | — | — | EP | disclosed |