SCHEMBL28568631

SCHEMBL28568631

Cc1ccc(COc2ccc(-c3nccc(C(=O)O)n3)cc2)cc1C#N

nearest known ligand 0.63

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
XDH P47989 12/20 0.63
MRGPRX4 Q96LA9 3/20 0.47
CYP4F2 P78329 1/20 0.45
CYP4A11 Q02928 1/20 0.45
PTGER4 P35408 1/20 0.41
MCL1 Q07820 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28577790 0.88 XDH (0.67) XDH
SCHEMBL28588707 0.88 XDH (0.63) XDHMRGPRX4CYP4F2CYP4A11MCL1
SCHEMBL28572338 0.88 XDH (0.63) XDHMRGPRX4CYP4F2CYP4A11MCL1
SCHEMBL28582833 0.88 XDH (0.63) XDHMRGPRX4CYP4F2CYP4A11MCL1
SCHEMBL28570876 0.87 XDH (0.62) XDHMRGPRX4CYP4F2CYP4A11
SCHEMBL28577380 0.83 XDH (0.61) XDHMRGPRX4
SCHEMBL28583439 0.82 XDH (0.61) XDHCYP4F2CYP4A11MCL1
SCHEMBL28574824 0.80 XDH (0.54) XDHMRGPRX4CYP4F2CYP4A11PTGER4
SCHEMBL28588699 0.76 XDH (0.54) XDHMRGPRX4CYP4F2CYP4A11
SCHEMBL28583441 0.76 XDH (0.71) XDHMRGPRX4CYP4F2CYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112979559-A 2-phenyl pyrimidine formic acid derivative and preparation method and application thereof 沈阳药科大学 2021-06-18 CN claimed
CN-112979559-A 2-phenyl pyrimidine formic acid derivative and preparation method and application thereof 沈阳药科大学 2021-06-18 CN disclosed