SCHEMBL28570876

SCHEMBL28570876

CC(C)(C)c1ccc(COc2ccc(-c3nccc(C(=O)O)n3)cc2)cc1C#N

nearest known ligand 0.62

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
XDH P47989 12/20 0.62
CYP4F2 P78329 1/20 0.43
CYP4A11 Q02928 1/20 0.43
MRGPRX4 Q96LA9 3/20 0.41
NR4A2 P43354 1/20 0.40
RXRA P19793 1/20 0.40
RXRB P28702 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28568631 0.87 XDH (0.63) XDHCYP4F2CYP4A11MRGPRX4
SCHEMBL28577790 0.85 XDH (0.67) XDH
SCHEMBL28572338 0.85 XDH (0.63) XDHCYP4F2CYP4A11MRGPRX4
SCHEMBL28588707 0.85 XDH (0.63) XDHCYP4F2CYP4A11MRGPRX4
SCHEMBL28582833 0.85 XDH (0.63) XDHCYP4F2CYP4A11MRGPRX4
SCHEMBL28584051 0.84 XDH (0.60) XDHMRGPRX4NR4A2RXRARXRB
SCHEMBL28589789 0.83 XDH (0.60) XDHMRGPRX4NR4A2
SCHEMBL28583439 0.80 XDH (0.61) XDHCYP4F2CYP4A11
SCHEMBL28574824 0.75 XDH (0.54) XDHCYP4F2CYP4A11MRGPRX4
SCHEMBL28588702 0.73 XDH (0.54) XDHCYP4F2CYP4A11MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112979559-A 2-phenyl pyrimidine formic acid derivative and preparation method and application thereof 沈阳药科大学 2021-06-18 CN claimed
CN-112979559-A 2-phenyl pyrimidine formic acid derivative and preparation method and application thereof 沈阳药科大学 2021-06-18 CN disclosed