Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 9/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 9/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL291879 | 0.88 | GABRA5 (0.54) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL286355 | 0.86 | GABRA5 (0.61) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL286344 | 0.86 | GABRA5 (0.67) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL286045 | 0.83 | GABRA5 (0.52) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL286659 | 0.83 | GABRA5 (0.52) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL286425 | 0.83 | GABRA5 (0.52) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL285797 | 0.83 | GABRA5 (0.65) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL285880 | 0.82 | GABRA5 (0.50) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL286645 | 0.80 | GABRA5 (0.55) | GABRA5 | |
| SCHEMBL2099669 | 0.79 | GABRA5 (0.60) | GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163728-B2 | Pyrazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |