Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 19/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL291879 | 0.92 | GABRA5 (0.54) | GABRA5 | |
| SCHEMBL286347 | 0.88 | GABRA5 (0.58) | GABRA5 | |
| SCHEMBL286289 | 0.88 | GABRA5 (0.65) | GABRA5 | |
| SCHEMBL286651 | 0.86 | GABRA5 (0.58) | GABRA5 | |
| SCHEMBL286552 | 0.83 | GABRA5 (0.56) | GABRA5 | |
| SCHEMBL286529 | 0.81 | GABRA5 (0.54) | GABRA5 | |
| SCHEMBL286055 | 0.81 | GABRA5 (0.66) | GABRA5 | |
| SCHEMBL1779475 | 0.81 | GABRA1 (0.61) | GABRA5 | |
| SCHEMBL285994 | 0.80 | GABRA5 (0.54) | GABRA5 | |
| SCHEMBL285692 | 0.80 | GABRA5 (0.51) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163728-B2 | Pyrazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |