Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.54 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28569396 | 0.91 | ALK (0.64) | IGF1RCDK2ALKINSRPTK2 | |
| SCHEMBL28952532 | 0.84 | ALK (0.47) | IGF1RCDK2ALKINSRPTK2 | |
| SCHEMBL28572359 | 0.83 | ALK (0.61) | IGF1RALKINSRPTK2 | |
| SCHEMBL28564190 | 0.81 | EGFR (0.64) | IGF1RALKINSRPTK2EGFR | |
| SCHEMBL28913878 | 0.78 | PTK2 (0.57) | IGF1RALKINSRPTK2EGFR | |
| SCHEMBL28913875 | 0.78 | PTK2 (0.57) | IGF1RALKINSRPTK2EGFR | |
| SCHEMBL28582736 | 0.75 | PTK2 (0.51) | IGF1RALKINSRPTK2EGFR | |
| SCHEMBL28567986 | 0.75 | INSR (0.58) | IGF1RALKINSRPTK2EGFR | |
| SCHEMBL28574074 | 0.75 | PTK2 (0.72) | IGF1RALKINSRPTK2EGFR | |
| SCHEMBL30173414 | 0.73 | IGF1R (0.49) | IGF1RCDK2ALKINSREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112771032-B | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-112771032-A | Pyrimidine pyrazole compounds as fourth generation EGFR inhibitors | 江苏先声药业有限公司 | 2021-05-07 | — | — | CN | disclosed |