SCHEMBL28574665

SCHEMBL28574665

OCc1c(C(F)F)nn(-c2ccc(F)cc2F)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.40
CNR1 P21554 12/20 0.36
CNR2 P34972 6/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
GCGR P47871 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28584133 0.87 P2RX7 (0.38) P2RX7CNR1CNR2L3MBTL1NPC1
SCHEMBL28567282 0.79 NOTUM (0.40) P2RX7
SCHEMBL2553686 0.76 L3MBTL1 (0.36) P2RX7CNR1CNR2L3MBTL1NPC1
SCHEMBL2561351 0.68 L3MBTL1 (0.38) P2RX7CNR1CNR2L3MBTL1NPC1
SCHEMBL28471474 0.66
SCHEMBL28471960 0.66 P2RX7 (0.30) P2RX7
SCHEMBL28575589 0.66 L3MBTL1 (0.40) CNR1CNR2L3MBTL1NPC1RAB9A
SCHEMBL28573697 0.66 P2RX7 (0.37) P2RX7
SCHEMBL3384730 0.66 KMT2A (0.30)
SCHEMBL2560689 0.64 L3MBTL1 (0.39) P2RX7CNR1CNR2L3MBTL1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112794846-B Ethyl isoxazoline derivative and application thereof 宁夏苏融达化工有限公司 2022-09-20 CN disclosed
CN-112794846-A Ethyl isoxazoline derivative and application thereof 东莞市东阳光农药研发有限公司 2021-05-14 CN disclosed