Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | GPR6 | P46095 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854966 | 0.91 | TACR3 (0.53) | TP53THRBPOLBKDM4EGPR6 | |
| SCHEMBL2850445 | 0.91 | LSS (0.51) | TP53THRBMAPTSMN1; SMN2SIGMAR1 | |
| SCHEMBL2857056 | 0.89 | KDM4E (0.50) | TP53THRBMAPTSMN1; SMN2POLB | |
| SCHEMBL2853001 | 0.88 | TACR3 (0.52) | TP53THRBMAPTSMN1; SMN2POLB | |
| SCHEMBL2854149 | 0.85 | TP53 (0.50) | TP53MAPTSMN1; SMN2POLBSIGMAR1 | |
| SCHEMBL2854134 | 0.84 | SIGMAR1 (0.52) | TP53THRBMAPTSMN1; SMN2SIGMAR1 | |
| SCHEMBL2854502 | 0.84 | CYP46A1 (0.53) | TP53THRBMAPTSMN1; SMN2POLB | |
| SCHEMBL2856126 | 0.83 | KDM4E (0.51) | TP53THRBMAPTSMN1; SMN2SIGMAR1 | |
| SCHEMBL2850576 | 0.83 | HTR7 (0.50) | TP53THRBMAPTSMN1; SMN2SIGMAR1 | |
| SCHEMBL2859283 | 0.83 | SMN1; SMN2 (0.51) | TP53THRBMAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |