Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074968 | 1.00 | MAPT (0.47) | MAPTHTTMAPK1SUV39H2ALDH1A1 | |
| SCHEMBL28578728 | 0.81 | MAPT (0.49) | MAPTHTTMAPK1SUV39H2ALDH1A1 | |
| SCHEMBL30074969 | 0.81 | MAPT (0.49) | MAPTHTTMAPK1SUV39H2ALDH1A1 | |
| SCHEMBL23629089 | 0.79 | JAK2 (0.51) | MAPTHTTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL30594931 | 0.77 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2CKS1B | |
| SCHEMBL29125356 | 0.77 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2CKS1B | |
| SCHEMBL31142866 | 0.77 | MAPT (0.49) | MAPTHTTMAPK1SUV39H2ALDH1A1 | |
| SCHEMBL29636799 | 0.77 | MAPT (0.46) | MAPTHTTSUV39H2ALDH1A1LMNA | |
| SCHEMBL23015375 | 0.77 | MAPT (0.46) | MAPTHTTSUV39H2ALDH1A1LMNA | |
| SCHEMBL30208188 | 0.76 | MAPT (0.72) | MAPTHTTMAPK1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493453-B | Condensed aromatic ring derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-06-16 | — | — | CN | disclosed |
| CN-112955432-B | Fused aromatic ring derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-113493453-A | Fused aromatic ring derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-10-12 | — | — | CN | disclosed |
| CN-112955432-A | Fused aromatic ring derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-06-11 | — | — | CN | disclosed |