Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23015375 | 1.00 | MAPT (0.46) | MAPTALDH1A1LMNAIDO1TDO2 | |
| SCHEMBL23015108 | 0.87 | ALDH1A1 (0.53) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL29636833 | 0.87 | ALDH1A1 (0.53) | MAPTALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL23015150 | 0.85 | SUV39H2 (0.51) | ALDH1A1SUV39H2NPSR1KDM4E | |
| SCHEMBL18031540 | 0.80 | SCN9A (0.56) | MAPTALDH1A1LMNAENPP2SMN1; SMN2 | |
| SCHEMBL23015171 | 0.80 | ACP1 (0.47) | MAPTIDO1TDO2IDO2ENPP2 | |
| SCHEMBL29636793 | 0.80 | ACP1 (0.47) | MAPTIDO1TDO2IDO2ENPP2 | |
| SCHEMBL26967706 | 0.80 | MAPT (0.46) | MAPTALDH1A1LMNAENPP2ALOX5 | |
| SCHEMBL805870 | 0.78 | SCN9A (0.65) | ENPP2GRIA1 | |
| SCHEMBL941160 | 0.78 | ALDH1A1 (0.62) | MAPTALDH1A1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | disclosed |