Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
| ▸ | CKS1B | P61024 | 2/20 | 0.46 |
| ▸ | SKP1 | P63208 | 2/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30074968 | 0.79 | MAPT (0.47) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL28575536 | 0.79 | MAPT (0.47) | CCNKCCNA2CDK2CCND3CDK9 | |
| SCHEMBL23575854 | 0.76 | MAPT (0.59) | ALDH1A1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL23575564 | 0.75 | CSF1R (0.54) | PTPN11SLC2A1 | |
| SCHEMBL13979397 | 0.74 | GPR119 (0.61) | JAK2JAK3NAMPTGPR119ALDH1A1 | |
| SCHEMBL12070614 | 0.73 | MAPT (0.50) | NAMPTGPR119ALDH1A1MAPTLMNA | |
| SCHEMBL17826997 | 0.73 | CHRM2 (0.50) | CKS1BSKP1SKP2ALDH1A1LMNA | |
| SCHEMBL12788964 | 0.73 | PDK2 (0.44) | JAK2JAK3CKS1BSKP1SKP2 | |
| SCHEMBL23575656 | 0.72 | MAPT (0.60) | ALDH1A1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL27236227 | 0.72 | RAD52 (0.67) | CCNKCCNA2CDK2CCND3CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846800-A1 | COMPOUNDS FOR THE DEGRADATION OF BRD9 OR MTH1 | C4 Therapeutics, Inc. (US) | 2021-07-14 | — | — | EP | disclosed |