Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 2/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10841724 | 0.83 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL2059084 | 0.83 | RAB9A (0.44) | NPC1RAB9AMEN1KMT2ADRD2 | |
| SCHEMBL610584 | 0.81 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL10223619 | 0.79 | KMT2A (0.48) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL6362002 | 0.73 | NPC1 (0.82) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL7448866 | 0.72 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL2234870 | 0.72 | MEN1 (0.72) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL6406394 | 0.72 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL18770955 | 0.72 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ASIGMAR1 | |
| SCHEMBL15791205 | 0.72 | NPC1 (0.72) | NPC1RAB9AMEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105777776-B | Inhibitors of protein tyrosine kinase activity | 梅特希尔基因公司 | 2021-06-08 | — | — | CN | disclosed |