SCHEMBL28575681

SCHEMBL28575681

O=CC(=O)C1c2ccccc2CN1C=C[N+](=O)[O-]

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ACE P12821 5/20 0.34
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30
FBP1 P09467 2/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28567508 0.79 ACE (0.37) ACEMEN1KMT2AALDH1A1MAPT
SCHEMBL27842630 0.78 ACE (0.39) ACEKMT2AALDH1A1HTT
SCHEMBL27920541 0.73 ACE (0.41) ACEMEN1KMT2AALDH1A1MAPT
Nitrobenzene SCHEMBL28128310 0.72 KMT2A (0.41) ACEMEN1KMT2AALDH1A1MAPT
SCHEMBL28361507 0.72 ACE (0.40) ACEMEN1KMT2AALDH1A1MAPT
SCHEMBL27982978 0.72 ACE (0.41) ACEMEN1KMT2AALDH1A1MAPT
SCHEMBL28812127 0.70 GBA1 (0.43) MEN1KMT2AALDH1A1MAPT
Benzene SCHEMBL28150775 0.70 ACE (0.42) ACEHTT
SCHEMBL28002392 0.70 ACE (0.42) ACEHTT
SCHEMBL28265026 0.69 ACE (0.36) ACEALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112812033-B Novel synthesis method of oseltamivir 山东大学 2022-02-15 CN disclosed
CN-112812033-B Novel synthesis method of oseltamivir 山东大学 2022-02-15 CN disclosed
CN-112812033-A Novel synthesis method of oseltamivir 山东大学 2021-05-18 CN disclosed
CN-112812033-A Novel synthesis method of oseltamivir 山东大学 2021-05-18 CN disclosed