Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 8/20 | 0.49 |
| ▸ | WIZ | O95785 | 3/20 | 0.48 |
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.46 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29167295 | 0.94 | CRBN (0.52) | CRBNWIZIKZF2CSNK1A1IKZF1 | |
| SCHEMBL30906267 | 0.85 | CRBN (0.52) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL20231475 | 0.85 | CRBN (0.52) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL31748857 | 0.85 | CRBN (0.53) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL21759799 | 0.85 | CRBN (0.53) | CRBNIKZF2CSNK1A1IKZF1 | |
| SCHEMBL29767388 | 0.84 | CRBN (0.55) | CRBNWIZIKZF2IKZF1 | |
| SCHEMBL27284747 | 0.84 | CRBN (0.55) | CRBNWIZIKZF2IKZF1 | |
| SCHEMBL27284718 | 0.84 | CRBN (0.55) | CRBNWIZIKZF2IKZF1 | |
| SCHEMBL30930637 | 0.84 | CRBN (0.55) | CRBNWIZIKZF2IKZF1 | |
| SCHEMBL24847721 | 0.84 | CRBN (0.53) | CRBNWIZIKZF2CSNK1A1IKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626927-B | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-115697989-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-115626927-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2023-01-20 | — | — | CN | disclosed |
| CN-112888681-A | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2021-06-01 | — | — | CN | disclosed |