Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.48 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.45 |
| ▸ | IKZF2 | Q9UKS7 | 6/20 | 0.45 |
| ▸ | WIZ | O95785 | 1/20 | 0.44 |
| ▸ | GSPT1 | P15170 | 3/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.43 |
| ▸ | SALL4 | Q9UJQ4 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28575914 | 0.94 | CRBN (0.49) | CRBNCSNK1A1IKZF1IKZF2WIZ | |
| SCHEMBL20231475 | 0.87 | CRBN (0.52) | CRBNCSNK1A1IKZF1IKZF2GSPT1 | |
| SCHEMBL30906267 | 0.87 | CRBN (0.52) | CRBNCSNK1A1IKZF1IKZF2GSPT1 | |
| SCHEMBL21759799 | 0.87 | CRBN (0.53) | CRBNCSNK1A1IKZF1IKZF2GSPT1 | |
| SCHEMBL31748857 | 0.87 | CRBN (0.53) | CRBNCSNK1A1IKZF1IKZF2GSPT1 | |
| SCHEMBL30689654 | 0.83 | IKZF2 (0.51) | CRBNCSNK1A1IKZF1IKZF2GSPT1 | |
| SCHEMBL30906316 | 0.82 | CRBN (0.50) | CRBNCSNK1A1IKZF1IKZF2WIZ | |
| SCHEMBL24186804 | 0.82 | CRBN (0.53) | CRBNCSNK1A1DDB1 | |
| SCHEMBL30906303 | 0.82 | CRBN (0.49) | CRBNIKZF1IKZF2 | |
| SCHEMBL30906224 | 0.82 | CRBN (0.49) | CRBNCSNK1A1IKZF1IKZF2WIZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115626927-B | Tropomyosin Receptor Kinase (TRK) degrading compounds and methods of use | 上海睿跃生物科技有限公司 | 2024-01-02 | — | — | CN | disclosed |