Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28574242 | 1.00 | HPGD (0.53) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL28574240 | 1.00 | HPGD (0.53) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL641371 | 0.90 | ALDH1A1 (0.61) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL641372 | 0.90 | ALDH1A1 (0.61) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL9882415 | 0.90 | ALDH1A1 (0.61) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL28914926 | 0.86 | HPGD (0.56) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL28571024 | 0.86 | HPGD (0.56) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL22570055 | 0.86 | HPGD (0.59) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL28571023 | 0.86 | HPGD (0.56) | HPGDALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL23210360 | 0.86 | HPGD (0.58) | HPGDALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112778299-B | Piperazine ureido derivatives, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-112778299-A | Piperazine ureido derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-05-11 | — | — | CN | disclosed |