Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.59 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.59 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | HTR2B | P41595 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28975143 | 0.95 | MAPT (0.63) | MAPTTSHRMAPK1LMNAADRB2 | |
| SCHEMBL1318123 | 0.78 | MEN1 (0.59) | MAPTTSHRMAPK1LMNAADRB2 | |
| SCHEMBL9428569 | 0.77 | TAAR1 (0.60) | MAPTTSHRMAPK1LMNAADRB2 | |
| SCHEMBL13532733 | 0.75 | HTR1A (0.94) | MAPTTSHRMAPK1LMNAADRB2 | |
| SCHEMBL23467818 | 0.74 | CHRM2 (0.97) | MAPTTSHRCYP3A4BLMPMP22 | |
| SCHEMBL22652639 | 0.74 | CHRM2 (0.97) | MAPTTSHRCYP3A4BLMPMP22 | |
| SCHEMBL16139561 | 0.74 | CHRM2 (0.97) | MAPTTSHRCYP3A4BLMPMP22 | |
| Urapidil SCHEMBL48992 | 0.74 | HTR1A (1.00) | MAPTTSHRMAPK1LMNAADRB2 | |
| Urapidil SCHEMBL29363219 | 0.74 | HTR1A (1.00) | MAPTTSHRMAPK1LMNAADRB2 | |
| SCHEMBL28577448 | 0.73 | CHRM2 (0.50) | CYP3A4ADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109516960-B | Preparation method of urapidil hydrochloride | 河北一品制药股份有限公司 | 2021-07-02 | — | — | CN | disclosed |