SCHEMBL28577673

SCHEMBL28577673

Nc1cc(O)cc(N)c1C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.36
CA1 P00915 2/20 0.36
CA9 Q16790 2/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA14 Q9ULX7 1/20 0.36
BACE1 P56817 1/20 0.35
USP7 Q93009 1/20 0.34
PTGS1 P23219 1/20 0.33
ALDH1A1 P00352 3/20 0.32
HSD17B10 Q99714 3/20 0.32
KDM4E B2RXH2 2/20 0.32
HPGD P15428 2/20 0.32
ALOX15 P16050 2/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
MAPT P10636 1/20 0.32
THRB P10828 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5515820 0.86 GLA (0.34) CA12CA1CA9CA2CA7
SCHEMBL29962951 0.76 PTPN5 (0.48) BACE1ALDH1A1HSD17B10KDM4EHPGD
SCHEMBL5520140 0.75 HSD17B10 (0.33) CA12CA1CA9CA2CA7
SCHEMBL9963466 0.74 IDO1 (0.33) ALDH1A1HSD17B10KDM4EALOX15MEN1
SCHEMBL28577674 0.72 NR4A1 (0.42) ALDH1A1HSD17B10KDM4EALOX15MEN1
SCHEMBL5515894 0.72 CA12 (0.37) CA12CA1CA9CA2CA7
SCHEMBL17914242 0.72 KDM4E (0.44) CA12CA1CA9CA2CA7
SCHEMBL759007 0.70 CA12 (0.41) CA12CA1CA9BACE1PTGS1
SCHEMBL395557 0.70 KIF11 (0.39) CA12CA1CA9BACE1PTGS1
SCHEMBL9769151 0.70 VRK1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112824435-A High-regularity thermoplastic polyurethane material and preparation method thereof 北京化工大学 2021-05-21 CN claimed
CN-113831493-B Self-repairing polyurethane elastomer containing six-fold intermolecular hydrogen bonds and preparation method thereof 中国科学院宁波材料技术与工程研究所 2023-07-18 CN disclosed
CN-112824435-A High-regularity thermoplastic polyurethane material and preparation method thereof 北京化工大学 2021-05-21 CN disclosed