SCHEMBL28577905

SCHEMBL28577905

O=[N+]([O-])c1ccc(-n2cnc(OP(O)(O)=S)n2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.43
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CES2 O00748 1/20 0.40
CES1 P23141 1/20 0.40
MAPT P10636 4/20 0.39
ALDH1A1 P00352 3/20 0.38
CYP3A4 P08684 2/20 0.38
MAPK1 P28482 2/20 0.38
HSD17B10 Q99714 2/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
THRB P10828 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
KDM4E B2RXH2 1/20 0.37
PPARG P37231 1/20 0.37
POLB P06746 1/20 0.36
TSHR P16473 1/20 0.35
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28577906 0.80 HTT (0.46) HTTCA1CA2CES2CES1
SCHEMBL28567432 0.79 ALDH1A1 (0.41) MAPTALDH1A1LMNAKDM4E
SCHEMBL28569244 0.74 HTT (0.51) HTTCA1CA2MAPTALDH1A1
SCHEMBL718100 0.71 HTT (0.59) HTTMAPTALDH1A1HSD17B10LMNA
SCHEMBL3758351 0.71 HTT (0.51) HTTMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL3751013 0.71 HTT (0.51) HTTMAPTALDH1A1CYP3A4LMNA
SCHEMBL27293604 0.71 HTT (0.51) HTTCA1CA2MAPTALDH1A1
SCHEMBL955844 0.70 CA1 (0.70) CA1CA2CES2CES1MAPT
SCHEMBL11068477 0.68 HTT (0.51) HTTMAPTALDH1A1LMNASMN1; SMN2
SCHEMBL3750773 0.68 HTT (0.51) HTTMAPTALDH1A1HSD17B10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112898343-A Hapten of organophosphorus triazophos pesticide and preparation method thereof 中国农业科学院蔬菜花卉研究所 2021-06-04 CN claimed
CN-112898343-A Hapten of organophosphorus triazophos pesticide and preparation method thereof 中国农业科学院蔬菜花卉研究所 2021-06-04 CN disclosed