Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | CTSG | P08311 | 2/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.45 |
| ▸ | CMA1 | P23946 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 4/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765430 | 1.00 | NPC1 (0.48) | NPC1RAB9AMAPTPRSS1CTSG | |
| SCHEMBL27794800 | 0.86 | CTSK (0.49) | NPC1RAB9AMAPTTSHRCTSS | |
| SCHEMBL14716956 | 0.86 | CTSK (0.49) | NPC1RAB9AMAPTTSHRCTSS | |
| SCHEMBL15311168 | 0.86 | CTSK (0.49) | NPC1RAB9AMAPTTSHRCTSS | |
| SCHEMBL27626876 | 0.84 | NPC1 (0.44) | NPC1RAB9AMAPTPRSS1CTSG | |
| SCHEMBL29046848 | 0.83 | NPC1 (0.43) | NPC1RAB9AMAPTPRSS1CTSG | |
| SCHEMBL28763879 | 0.81 | PPARA (0.46) | NPC1RAB9AMAPTCTSSSCN9A | |
| SCHEMBL28533077 | 0.81 | PPARA (0.46) | NPC1RAB9AMAPTCTSSSCN9A | |
| SCHEMBL29060746 | 0.78 | CTSK (0.47) | NPC1RAB9AMAPTCTRB1CTSS | |
| SCHEMBL18114457 | 0.76 | LMNA (0.47) | TSHRMMP12KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112867706-A | MASP-2 inhibitors and methods of use | 奥默罗斯公司 | 2021-05-28 | — | — | CN | disclosed |