Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 13/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 9/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28580870 | 0.87 | JAK1 (0.35) | JAK1JAK2EGLN1JAK3AURKA | |
| SCHEMBL21724518 | 0.76 | JAK1 (0.53) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL21724877 | 0.71 | JAK1 (0.50) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL21724622 | 0.71 | JAK1 (0.38) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL20476279 | 0.69 | NLRP3 (0.39) | EGLN1MMP1MMP9MMP13 | |
| SCHEMBL26619954 | 0.67 | PREP (0.37) | PREP | |
| SCHEMBL26619957 | 0.67 | PREP (0.37) | PREP | |
| SCHEMBL5415670 | 0.65 | PPARG (0.39) | EGLN1MMP1MMP9MMP13 | |
| SCHEMBL3873767 | 0.65 | P2RX3 (0.38) | — | |
| SCHEMBL3862503 | 0.64 | P2RX3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112996567-A | Imidazo [4,5-C ] quinoline-derived NLRP 3-modulators | 先天肿瘤免疫公司 | 2021-06-18 | — | — | CN | disclosed |