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Sugi Predict / Compounds / SCHEMBL285826

SCHEMBL285826

SCHEMBL285826

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4CC(OC5CC[C@@]6(C)C(=CC[C@H]7[C@@H]8CC[C@H]([C@H](C)CCCC(C)C)[C@@]8(C)CC[C@@H]76)C5)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP46A1 Q9Y6A2 2/20 0.78
▸ POLA1 P09884 1/20 0.77
▸ OSBP P22059 4/20 0.77
▸ RORC P51449 3/20 0.77
▸ USP2 O75604 2/20 0.77
▸ OSBP2 Q969R2 2/20 0.77
▸ LMNA P02545 1/20 0.77
▸ ABCB1 P08183 1/20 0.77
▸ GRIN1 Q05586 2/20 0.65
▸ GRIN2A Q12879 2/20 0.65
▸ NR1H3 Q13133 3/20 0.65
▸ GBA1 P04062 2/20 0.64
▸ UGCG Q16739 2/20 0.64
▸ GBA2 Q9HCG7 2/20 0.64
▸ NPC1L1 Q9UHC9 3/20 0.62
▸ CRYAB P02511 1/20 0.62
▸ HMGCR P04035 1/20 0.62
▸ ITGB3 P05106 1/20 0.62
▸ ITGAV P06756 1/20 0.62
▸ SREBF2 Q12772 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27545186 1.00 CYP46A1 (0.78) CYP46A1POLA1OSBPRORCUSP2
SCHEMBL93852 1.00 CYP46A1 (0.78) CYP46A1POLA1OSBPRORCUSP2
Ethylene Glycol SCHEMBL5191546 0.96 CYP46A1 (0.76) CYP46A1POLA1OSBPRORCUSP2
SCHEMBL28900503 0.95 CYP46A1 (0.72) CYP46A1POLA1OSBPRORCUSP2
Bicarbonate SCHEMBL10867435 0.95 POLA1 (0.82) CYP46A1POLA1OSBPRORCUSP2
SCHEMBL680552 0.94 CYP46A1 (0.78) CYP46A1POLA1OSBPRORCUSP2
SCHEMBL24405093 0.93 CYP46A1 (0.77) CYP46A1POLA1OSBPRORCUSP2
SCHEMBL20924867 0.93 CYP46A1 (0.77) CYP46A1POLA1OSBPRORCUSP2
SCHEMBL15150903 0.93 CYP46A1 (0.77) CYP46A1POLA1OSBPRORCUSP2
SCHEMBL21707464 0.93 CYP46A1 (0.77) CYP46A1POLA1OSBPRORCUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 504 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11554086-B2 Cosmetic composition comprising glycolic acid and methods of use L'OREAL (FR) 2023-01-17 — — US claimed
CN-115286676-A Synthetic method for preparing cholesterol methyl ether from diosgenin 沈阳化工研究院有限公司 2022-11-04 — — CN claimed
EP-3743036-A1 COSMETIC COMPOSITION COMPRISING GLYCOLIC ACID AND METHODS OF USE L'OREAL (FR) 2020-12-02 — — EP claimed
US-20190201304-A1 COSMETIC COMPOSITION COMPRISING GLYCOLIC ACID AND METHODS OF USE L'OREAL (FR) 2019-07-04 — — US claimed
EP-3173064-B1 OIL-IN-WATER EMULSION GEL COMPOSITION, EXTERNAL PREPARATION FOR SKIN AND PRODUCING METHOD OF OIL-IN-WATER EMULSION COMPOSITION FUJIFILM CORP (JP) 2018-09-12 — — EP claimed
WO-2017157950-A1 LIGHT INDUCIBLE ANTISENSE OLIGONUCLEOTIDES FOR IN VIVO APPLICATION Johann Wolfgang Goethe-Universität (DE) 2017-09-21 — — WO claimed
EP-3173064-A1 OIL-IN-WATER EMULSION GEL COMPOSITION, EXTERNAL PREPARATION FOR SKIN AND PRODUCING METHOD OF OIL-IN-WATER EMULSION COMPOSITION Fujifilm Corporation (JP) 2017-05-31 — — EP claimed
US-20120128761-A1 Lipophilic Polynucleotide Conjugates MiRagen Therapeutics, Inc. (US) 2012-05-24 — — US claimed
CN-102459301-A Lipophilic polynucleotide conjugates MIRAGEN THERAPEUTICS 2012-05-16 — — CN claimed
EP-2427472-A1 LIPOPHILIC POLYNUCLEOTIDE CONJUGATES Miragen Therapeutics (US) 2012-03-14 — — EP claimed
EP-1328190-A2 TEMPERATURE MEASURING BALLOON Boston Scientific Limited (BB) 2003-07-23 — — EP claimed
EP-1272465-A2 COMPOUNDS AND METHODS TO INCREASE PLASMA HDL CHOLESTEROL LEVELS AND IMPROVE HDL FUNCTIONALITY Atherogenics, Inc. (US) 2003-01-08 — — EP claimed
US-6450971-B1 Temperature measuring balloon SCIMED LIFE SYSTEMS, INC. 2002-09-17 — — US claimed
WO-2002028276-A2 TEMPERATURE MEASURING BALLOON SCIMED LIFE SYSTEMS, INC. (US) 2002-04-11 — — WO claimed
US-20020016364-A1 Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality CRABTREE ACQUISITION CO, LLC 2002-02-07 — — US claimed
WO-2001077072-A2 COMPOUNDS AND METHODS TO INCREASE PLASMA HDL CHOLESTEROL LEVELS AND IMPROVE HDL FUNCTIONALITY ATHEROGENICS, INC. (US) 2001-10-18 — — WO claimed
EP-0845265-A1 MUCOSAL PREPARATION CONTAINING PHYSIOLOGICALLY ACTIVE PEPTIDE Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1998-06-03 — — EP claimed
US-5759565-A DRUG FOR NASAL ADMINISTRATION NOVARTIS CORPORATION (US) 1998-06-02 — — US claimed
CN-1179723-A Mucosal preparation containing physiologically active peptide ASAHI CHEMICAL IND (JP) 1998-04-22 — — CN claimed
US-3975287-A Liquid crystal composition for electric field indication KANSAI PAINT COMPANY, LTD. (JA) 1976-08-17 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190201304-A1 COSMETIC COMPOSITION COMPRISING GLYCOLIC ACID AND METHODS OF USE CUTA, UGCG, DGKI CYP46A1 767/4885POLA1 857/4885OSBP 2252/4885
US-20120128761-A1 Lipophilic Polynucleotide Conjugates NPC1L1, NPC1, NCL CYP46A1 172/4885POLA1 244/4885OSBP 546/4885
US-11554086-B2 Cosmetic composition comprising glycolic acid and methods of use CUTA, UGCG, DGKI CYP46A1 767/4885POLA1 857/4885OSBP 2252/4885
US-20020016364-A1 Compounds and methods to increase plasma HDL cholesterol levels and improve HDL functionality HDLBP, CETP, APOB CYP46A1 20/4885POLA1 4391/4885OSBP 90/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.