Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.36 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3722511 | 0.98 | HTR2A (0.40) | HTR2AKCNH2L3MBTL1MEN1KMT2A | |
| Trifluoromethanesulfonic Acid SCHEMBL17822648 | 0.84 | KCNH2 (0.40) | KCNH2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1457612 | 0.81 | TAAR1 (0.42) | HTR2AKCNH2MEN1KMT2AADRA2A | |
| SCHEMBL521938 | 0.79 | CALM1 (0.41) | HTR2AKCNH2MEN1KMT2ADRD3 | |
| Hydrochloric Acid SCHEMBL193045 | 0.77 | HRH3 (0.33) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2831078 | 0.75 | HRH3 (0.32) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2939802 | 0.75 | — | — | |
| SCHEMBL107551 | 0.74 | HRH3 (0.34) | KCNH2 | |
| Pyridine SCHEMBL7142615 | 0.74 | HRH3 (0.34) | KCNH2L3MBTL1MEN1KMT2ACHRM2 | |
| Hydrochloric Acid SCHEMBL2830743 | 0.74 | KCNH2 (0.39) | HTR2AKCNH2MEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065770-A2 | POLYMERIZED POLYMERIC FLUID STORAGE AND PURIFICATION METHOD AND SYSTEM | MATHESON TRI-GAS (US) | 2010-06-10 | — | — | WO | disclosed |