SCHEMBL28583448

SCHEMBL28583448

c1coc(-c2ccccc2-c2ccc3ccccc3c2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.53
BRD4 O60885 1/20 0.48
TDP1 Q9NUW8 2/20 0.47
PIK3R1 P27986 5/20 0.46
PIK3CA P42336 5/20 0.46
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
PGR P06401 1/20 0.44
CYP1A2 P05177 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
ESR2 Q92731 2/20 0.40
TAAR1 Q96RJ0 1/20 0.40
ESR1 P03372 1/20 0.40
ALDH1A1 P00352 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2723898 0.85 PGR (0.57) GSTP1BRD4TDP1PIK3R1PIK3CA
SCHEMBL28508645 0.80 GSTP1 (0.70) GSTP1TDP1CYP11B1CYP11B2HDAC4
SCHEMBL30491158 0.80 GSTP1 (0.70) GSTP1TDP1CYP11B1CYP11B2HDAC4
SCHEMBL24309147 0.79 PGR (0.56) GSTP1BRD4TDP1PIK3R1PIK3CA
SCHEMBL26259745 0.78 PGR (0.62) BRD4TDP1PIK3R1PIK3CACYP11B1
SCHEMBL28879160 0.77 KDM4E (0.49) TDP1PIK3R1PIK3CATAAR1ESR1
SCHEMBL29755699 0.77 KDM4E (0.51) TDP1PIK3R1PIK3CATAAR1ESR1
SCHEMBL7116127 0.77 KDM4E (0.51) TDP1PIK3R1PIK3CATAAR1ESR1
SCHEMBL26259868 0.77 PGR (0.61) BRD4TDP1PIK3R1PIK3CACYP11B1
SCHEMBL29274331 0.76 GSTP1 (0.64) GSTP1TDP1CYP11B1CYP11B2HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112939903-B Method for preparing furan compounds from bromoaryl ketone 重庆医科大学 2023-05-26 CN disclosed
CN-112939903-A Method for preparing furan compound from aryl ketone bromide 重庆医科大学 2021-06-11 CN disclosed