Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.41 |
| ▸ | ADH1B | P00325 | 1/20 | 0.41 |
| ▸ | ADH1C | P00326 | 1/20 | 0.41 |
| ▸ | ADH1A | P07327 | 1/20 | 0.41 |
| ▸ | ADH4 | P08319 | 1/20 | 0.41 |
| ▸ | ADH7 | P40394 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL745703 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL7702557 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL15973371 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL15109890 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL118049 | 0.98 | ALDH1A1 (0.59) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL283010 | 0.96 | ALDH1A1 (0.56) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL9575896 | 0.96 | ALDH1A1 (0.56) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL6546522 | 0.96 | ALDH1A1 (0.56) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| Hydrochloric Acid SCHEMBL5163421 | 0.96 | ALDH1A1 (0.56) | ALDH1A1TSHRS1PR2S1PR4S1PR1 | |
| SCHEMBL4230818 | 0.89 | TSHR (0.50) | ALDH1A1TSHRS1PR2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1681316-B1 | POLYLACTIC ACID RESIN COMPOSITION, PROCESS FOR PRODUCING THE SAME AND MOLDING THEREOF | TOYOTA MOTOR CO LTD (JP) | 2010-01-20 | — | — | EP | disclosed |
| US-20070032631-A1 | Polylactic acid resin composition, process for producing the same and molding thereof | TJOYOTA JIDOSHA KABUSHIKI KAISHA (JP) | 2007-02-08 | — | — | US | disclosed |
| US-7084192-B2 | Polylactic acid composite material and molded body | Kabushiki Kaisha Toyota Chuo Kankyusho (JP) | 2006-08-01 | — | — | US | disclosed |
| EP-1681316-A1 | POLYLACTIC ACID RESIN COMPOSITION, PROCESS FOR PRODUCING THE SAME AND MOLDING THEREOF | TOYOTA JIDOSHA KABUSHIKI KAISHA (JP) | 2006-07-19 | — | — | EP | disclosed |
| US-20040054051-A1 | Polylactic acid composite material and molded body | KABUSHIKI KAISHA TOYOTA CHUO KENKYUSHO (JP) | 2004-03-18 | — | — | US | disclosed |