Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 15/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30411986 | 0.91 | DHPS (1.00) | DHPS | |
| SCHEMBL28566926 | 0.91 | DHPS (1.00) | DHPS | |
| SCHEMBL28577446 | 0.88 | DHPS (0.83) | DHPSSMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL7851372 | 0.86 | DHPS (0.84) | DHPSSMN1; SMN2 | |
| SCHEMBL7303389 | 0.86 | DHPS (0.81) | DHPSALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL28589425 | 0.85 | DHPS (0.84) | DHPS | |
| SCHEMBL28584109 | 0.85 | DHPS (0.65) | DHPS | |
| SCHEMBL30450864 | 0.85 | DHPS (0.84) | DHPS | |
| SCHEMBL28584053 | 0.85 | DHPS (0.82) | DHPSTSHRLMNA | |
| SCHEMBL6964288 | 0.82 | DHPS (0.61) | DHPSALDH1A1MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112898208-B | Phenylpyrimidine amine antitumor compound and preparation method and application thereof | 中国医科大学 | 2023-06-20 | — | — | CN | disclosed |
| CN-112898208-A | Phenyl pyrimidinamine antitumor compound and preparation method and application thereof | 中国医科大学 | 2021-06-04 | — | — | CN | disclosed |