Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA5A | P35218 | 1/20 | 0.62 |
| ▸ | CFTR | P13569 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191567 | 0.94 | CA2 (0.68) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL19809604 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL191417 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL19895693 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL19809596 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL190541 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL672826 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL226388 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| SCHEMBL19809603 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR | |
| Hydrochloric Acid SCHEMBL2361106 | 0.92 | CA2 (0.65) | CA2CA4CA5ACFTRTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707225-B | Method for synthesizing polycarbonate in presence of bimetallic catalyst and chain transfer agent | IP2IPO创新有限公司 | 2021-07-02 | — | — | CN | disclosed |