Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.56 |
| ▸ | PRNP | P04156 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17973604 | 0.98 | MCL1 (0.57) | MCL1PRNPRXFP1HDAC1HDAC8 | |
| SCHEMBL6598312 | 0.86 | MAOB (0.46) | MCL1PRNPRXFP1HDAC1HDAC8 | |
| Lithium Ion SCHEMBL17960200 | 0.82 | RXFP1 (0.43) | MCL1PRNPRXFP1HDAC1HDAC8 | |
| SCHEMBL17960110 | 0.81 | LMNA (0.65) | RXFP1HDAC1HDAC8HDAC6LMNA | |
| SCHEMBL21874448 | 0.78 | GPR35 (0.45) | MCL1PRNPEDNRAPTPN2PTPN1 | |
| SCHEMBL17173227 | 0.78 | MCL1 (0.51) | MCL1PRNPRXFP1LMNAKDM4E | |
| SCHEMBL584871 | 0.75 | RXFP1 (0.71) | MCL1PRNPRXFP1HDAC1HDAC8 | |
| SCHEMBL29939764 | 0.75 | RXFP1 (0.71) | MCL1PRNPRXFP1HDAC1HDAC8 | |
| SCHEMBL346530 | 0.75 | MCL1 (0.62) | MCL1PRNPRXFP1HDAC1HDAC8 | |
| SCHEMBL28865810 | 0.75 | MCL1 (0.47) | MCL1PRNPRXFP1HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107873023-B | 3-alkyl-4-amido-bicyclo [4, 5, 0] hydroxamic acids as HDAC inhibitors | 福马治疗股份有限公司 | 2021-07-23 | — | — | CN | disclosed |