Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411648 | 0.92 | BACE1 (0.40) | BACE1DPP4DPP8DPP7OPRM1 | |
| SCHEMBL29181819 | 0.81 | BACE1 (0.37) | BACE1 | |
| SCHEMBL31048975 | 0.75 | BACE1 (0.42) | BACE1 | |
| SCHEMBL23314044 | 0.74 | — | — | |
| SCHEMBL31551850 | 0.74 | BACE1 (0.41) | BACE1DPP4DPP8 | |
| SCHEMBL28978262 | 0.69 | BACE1 (0.42) | BACE1 | |
| SCHEMBL698104 | 0.69 | BACE1 (0.43) | BACE1 | |
| SCHEMBL28574182 | 0.69 | — | — | |
| SCHEMBL24535005 | 0.68 | PIK3CA (0.43) | BACE1 | |
| SCHEMBL29679895 | 0.68 | KDM4E (0.39) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2230241-B1 | TETRAHYDRO-IMIDAZO[1,5-A]PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2014-11-26 | — | — | EP | disclosed |
| EP-2230241-A1 | TETRAHYDRO-IMIDAZOÝ1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-09-22 | — | — | EP | disclosed |
| CN-101641361-A | Tetrahydroimidazo [1, 5-a ] pyrazine derivative, preparation method and application thereof in medicine | SHANGHAI HENGRUI PHARM CO LTD | 2010-02-03 | — | — | CN | disclosed |