Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | PPIA | P62937 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL956763 | 0.86 | BACE1 (0.40) | BACE1ALDH1A1SMN1; SMN2MAOBCASP3 | |
| SCHEMBL411648 | 0.81 | BACE1 (0.40) | BACE1HCAR2 | |
| SCHEMBL8320979 | 0.79 | BACE1 (0.42) | BACE1SMN1; SMN2TSHRLMNA | |
| SCHEMBL29181819 | 0.78 | BACE1 (0.37) | BACE1 | |
| SCHEMBL28978262 | 0.77 | BACE1 (0.42) | BACE1 | |
| SCHEMBL698104 | 0.77 | BACE1 (0.43) | BACE1ALDH1A1HIF1ASMN1; SMN2TSHR | |
| SCHEMBL31551850 | 0.76 | BACE1 (0.41) | BACE1ALDH1A1HIF1AMAOBMAPT | |
| SCHEMBL2858880 | 0.75 | BACE1 (0.35) | BACE1 | |
| SCHEMBL17347945 | 0.75 | MAPT (0.40) | BACE1ALDH1A1MAOBMAPT | |
| SCHEMBL7993318 | 0.75 | BACE1 (0.51) | BACE1ALDH1A1SMN1; SMN2MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024167922-A2 | HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-08-15 | — | — | WO | disclosed |