Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285730 | 0.84 | GABRA5 (0.48) | KMT2AMEN1GABRA5HDAC6HDAC1 | |
| SCHEMBL2749573 | 0.84 | GABRA5 (0.48) | KMT2AMEN1GABRA5HDAC6HDAC1 | |
| SCHEMBL286104 | 0.84 | POLB (0.44) | KMT2AMEN1GAAHDAC6HDAC1 | |
| SCHEMBL285991 | 0.83 | CACNA1F (0.47) | GABRA5HDAC6HDAC1POLBADORA3 | |
| SCHEMBL285992 | 0.83 | CACNA1F (0.47) | GABRA5HDAC6HDAC1POLBADORA3 | |
| SCHEMBL286234 | 0.83 | HDAC6 (0.45) | KMT2AMEN1GAAGABRA5HDAC6 | |
| SCHEMBL286233 | 0.83 | HDAC6 (0.45) | KMT2AMEN1GAAGABRA5HDAC6 | |
| SCHEMBL285891 | 0.79 | GABRA5 (0.51) | GABRA5HDAC6HDAC1ALDH1A1HSD17B10 | |
| SCHEMBL295001 | 0.79 | GABRA5 (0.54) | GABRA5 | |
| SCHEMBL2749575 | 0.77 | HDAC6 (0.48) | KMT2AMEN1GAAGABRA5HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |