Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285991 | 0.90 | CACNA1F (0.47) | POLBALOX15TSHRMAPK1L3MBTL1 | |
| SCHEMBL285992 | 0.90 | CACNA1F (0.47) | POLBALOX15TSHRMAPK1L3MBTL1 | |
| SCHEMBL285892 | 0.84 | KMT2A (0.41) | POLBMEN1GAAKMT2AL3MBTL1 | |
| SCHEMBL286234 | 0.83 | HDAC6 (0.45) | POLBMEN1GAAKMT2AL3MBTL1 | |
| SCHEMBL286233 | 0.83 | HDAC6 (0.45) | POLBMEN1GAAKMT2AL3MBTL1 | |
| SCHEMBL286049 | 0.83 | GABRA5 (0.43) | GAAALDH1A1NPC1 | |
| SCHEMBL286183 | 0.83 | POLB (0.44) | POLBALOX15TSHRMAPK1MEN1 | |
| SCHEMBL285730 | 0.81 | GABRA5 (0.48) | POLBMEN1KMT2AL3MBTL1HDAC6 | |
| SCHEMBL2749573 | 0.81 | GABRA5 (0.48) | POLBMEN1KMT2AL3MBTL1HDAC6 | |
| SCHEMBL286248 | 0.79 | GABRA5 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-A1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |