Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2858994 | 1.00 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2D6HPGDALDH1A1 | |
| SCHEMBL2849126 | 0.96 | TYR (0.60) | CYP1A2CYP3A4CYP2D6HPGDALDH1A1 | |
| SCHEMBL2849129 | 0.96 | TYR (0.60) | CYP1A2CYP3A4CYP2D6HPGDALDH1A1 | |
| SCHEMBL2859265 | 0.91 | TYR (0.61) | TRPV1 | |
| SCHEMBL2859270 | 0.91 | TYR (0.61) | TRPV1 | |
| SCHEMBL2847211 | 0.87 | TYR (0.61) | TRPV1 | |
| SCHEMBL2847215 | 0.87 | TYR (0.61) | TRPV1 | |
| SCHEMBL802713 | 0.86 | ABCB1 (0.65) | TRPV1 | |
| SCHEMBL12299018 | 0.85 | TYR (0.73) | CYP1A2CYP3A4CYP2D6HPGDALDH1A1 | |
| SCHEMBL1916293 | 0.85 | TYR (0.73) | CYP1A2CYP3A4CYP2D6HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778622-B1 | PARA-ALKYL-SUBSTITUTED N-(4-HYDROXY-3-METHOXY-BENZYL) CINNAMAMIDES AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2010-01-13 | — | — | EP | claimed |
| US-7541495-B2 | para-alkyl-substituted N-(4-hydroxy-3-methoxy-benzyl)-cinnamamides, pharmaceutical compositions and uses thereof | GRUENENTHAL GMBH (DE) | 2009-06-02 | — | — | US | claimed |
| US-20070208083-A1 | Alkyl-substituted N-(4-hydroxy-3-methoxy-benzyl)-cinnamamides, pharmaceutical compositions and uses thereof | GRUENENTHAL GMBH (DE) | 2007-09-06 | — | — | US | claimed |
| US-7541495-B2 | para-alkyl-substituted N-(4-hydroxy-3-methoxy-benzyl)-cinnamamides, pharmaceutical compositions and uses thereof | GRUENENTHAL GMBH (DE) | 2009-06-02 | — | — | US | disclosed |
| US-20070208083-A1 | Alkyl-substituted N-(4-hydroxy-3-methoxy-benzyl)-cinnamamides, pharmaceutical compositions and uses thereof | GRUENENTHAL GMBH (DE) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208083-A1 | Alkyl-substituted N-(4-hydroxy-3-methoxy-benzyl)-cinnamamides, pharmaceutical compositions and uses thereof | CES2, GAA, EGLN3 | CYP1A2 186/4885CYP3A4 85/4885CYP2D6 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.