Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.63 |
| ▸ | PRKCG | P05129 | 1/20 | 0.63 |
| ▸ | INSR | P06213 | 1/20 | 0.63 |
| ▸ | CDK1 | P06493 | 1/20 | 0.63 |
| ▸ | FES | P07332 | 1/20 | 0.63 |
| ▸ | IGF1R | P08069 | 1/20 | 0.63 |
| ▸ | ROS1 | P08922 | 1/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.63 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.63 |
| ▸ | FER | P16591 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | MARK3 | P27448 | 1/20 | 0.63 |
| ▸ | FLT4 | P35916 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28603327 | 0.83 | DYRK1A (0.63) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL28614283 | 0.82 | JAK2 (0.75) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL28603325 | 0.80 | DYRK1A (0.67) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL1516750 | 0.78 | JAK2 (1.00) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL2238094 | 0.77 | CDK5 (0.66) | CDK1CDK2CDK5PDPK1GSK3B | |
| SCHEMBL28560103 | 0.76 | LRRK2 (0.48) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL15333224 | 0.76 | DYRK1A (0.74) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL1487549 | 0.76 | CDK8 (0.67) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL1516629 | 0.75 | DYRK1A (0.73) | DYRK1APLK4AURKAJAK2ROCK2 | |
| SCHEMBL21417046 | 0.75 | CDK2 (0.72) | DYRK1APLK4AURKAJAK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214247-A | Azaindole derivative marrow cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-08-06 | — | — | CN | disclosed |