Clarithromycin

SCHEMBL28595772

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nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Clarithromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CYP3A4	P08684	10/20	0.95

▸	KCNH2	Q12809	5/20	0.95

▸	SLCO1B3	Q9NPD5	3/20	0.95

▸	SLCO1B1	Q9Y6L6	3/20	0.95

▸	ABCB1	P08183	2/20	0.95

▸	MAPK1	P28482	2/20	0.95

▸	AR	P10275	1/20	0.95

▸	MLNR	O43193	2/20	0.88

▸	TSHR	P16473	2/20	0.88

▸	LMNA	P02545	2/20	0.88

▸	TDP1	Q9NUW8	1/20	0.88

▸	ALB	P02768	1/20	0.88

▸	CNR1	P21554	1/20	0.88

▸	HTR2A	P28223	1/20	0.88

▸	AOX1	Q06278	1/20	0.88

▸	CYP1B1	Q16678	1/20	0.88

▸	ABCB11	O95342	2/20	0.80

▸	ABCC4	O15439	1/20	0.80

▸	PGR	P06401	1/20	0.74

▸	HTR1A	P08908	1/20	0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Clarithromycin SCHEMBL7870339	0.98	CYP3A4 (0.94)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL7870336	0.98	CYP3A4 (0.94)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL5971354	0.97	CYP3A4 (0.92)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL5971358	0.97	CYP3A4 (0.92)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL23309064	0.97	CYP3A4 (1.00)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL38125	0.97	CYP3A4 (1.00)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL17616076	0.97	CYP3A4 (1.00)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL23854898	0.97	CYP3A4 (1.00)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL12296733	0.97	CYP3A4 (1.00)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1
Clarithromycin SCHEMBL17705916	0.97	CYP3A4 (1.00)	CYP3A4KCNH2SLCO1B3SLCO1B1ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-113913450-A	Method for expressing chitosanase by using rhodopseudomonas palustris, chitosanase, recombinant plasmid, recombinant bacterium, fermentation inoculant and application	湖南省植物保护研究所	2022-01-11	—	—	CN	claimed
CN-114832783-B	Adsorption material, preparation method and cleaning method	成都思文凌云科技有限公司	2024-03-12	—	—	CN	disclosed
CN-114832783-A	Adsorbing material, preparation method and cleaning method	成都思文凌云科技有限公司	2022-08-02	—	—	CN	disclosed
CN-113186208-B	Eukaryotic recombinant plasmid and application thereof in improving tomato fruit pigment accumulation	合肥工业大学	2022-07-15	—	—	CN	disclosed
CN-114527054-A	Method for researching stability and intracellular localization of phosphorylated p53 based on phase separation	华南理工大学	2022-05-24	—	—	CN	disclosed
CN-113913450-A	Method for expressing chitosanase by using rhodopseudomonas palustris, chitosanase, recombinant plasmid, recombinant bacterium, fermentation inoculant and application	湖南省植物保护研究所	2022-01-11	—	—	CN	disclosed
CN-113186208-A	Eukaryotic recombinant plasmid and application thereof in improving tomato fruit pigment accumulation	合肥工业大学	2021-07-30	—	—	CN	disclosed