Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.72 |
| ▸ | KIT | P10721 | 2/20 | 0.72 |
| ▸ | FLT1 | P17948 | 2/20 | 0.72 |
| ▸ | BRAF | P15056 | 11/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | RIPK3 | Q9Y572 | 4/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4288809 | 0.87 | KDR (0.61) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL2860515 | 0.86 | KDR (0.62) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL4285542 | 0.85 | KDR (0.69) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL3671088 | 0.84 | KDR (1.00) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL2853887 | 0.83 | KDR (0.64) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL2860133 | 0.83 | KDR (0.55) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL4293702 | 0.83 | KDR (0.77) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL4284219 | 0.83 | KDR (0.70) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL2851381 | 0.82 | BRAF (0.77) | KDRPDGFRBKITFLT1BRAF | |
| SCHEMBL14949669 | 0.82 | BRAF (0.55) | KDRPDGFRBKITFLT1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |