Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 9/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28587267 | 0.92 | HTR6 (0.39) | HTR6MEN1GFERKMT2ADRD2 | |
| Cadaverine Tartrate SCHEMBL28592976 | 0.92 | HTR6 (0.36) | HTR6PTGDRPTGDR2FABP4FABP5 | |
| SCHEMBL20679767 | 0.85 | HTR6 (0.35) | HTR6PTGDRPTGDR2FABP4FABP5 | |
| Abeprazan SCHEMBL19385601 | 0.84 | FABP4 (0.38) | HTR6PTGDRPTGDR2FABP4FABP5 | |
| SCHEMBL20679762 | 0.83 | HTR6 (0.35) | HTR6ALDH1A1MEN1GFERKMT2A | |
| Abeprazan SCHEMBL29201783 | 0.81 | FABP4 (0.37) | HTR6PTGDRPTGDR2FABP4FABP5 | |
| SCHEMBL20679764 | 0.81 | HTR6 (0.35) | HTR6MEN1GFERKMT2ADRD2 | |
| SCHEMBL29201835 | 0.80 | HTR6 (0.34) | HTR6MEN1GFERKMT2ADRD2 | |
| SCHEMBL19385605 | 0.78 | MEN1 (0.42) | HTR6PTGDRPTGDR2ALDH1A1MEN1 | |
| SCHEMBL30963571 | 0.78 | MEN1 (0.42) | HTR6PTGDRPTGDR2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602772-B | Novel crystal form of 1- (5- (2, 4-difluorophenyl) -1- ((3-fluorophenyl) sulfonyl) -4-methoxy-1H-pyrrole-3-yl) -N-methylmelamine salt | 株式会社大熊制药 | 2021-06-04 | — | — | CN | disclosed |