Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.43 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18188230 | 0.82 | NPC1 (0.43) | ROCK2ULK1POLBMEN1KMT2A | |
| SCHEMBL18188436 | 0.74 | MKNK1 (0.53) | ROCK2ULK1MEN1KMT2AROCK1 | |
| SCHEMBL29542975 | 0.74 | MKNK1 (0.53) | ROCK2ULK1MEN1KMT2AROCK1 | |
| SCHEMBL30272857 | 0.73 | SYK (0.46) | ROCK2ULK1ROCK1MKNK1HSF1 | |
| SCHEMBL18188218 | 0.71 | ROCK2 (0.46) | ROCK2POLBMEN1KMT2AROCK1 | |
| SCHEMBL18188414 | 0.71 | NPC1 (0.52) | ROCK2MEN1KMT2AROCK1NPC1 | |
| SCHEMBL30272874 | 0.69 | SYK (0.47) | ROCK2ULK1ROCK1MKNK1RET | |
| SCHEMBL16834423 | 0.65 | NPC1 (0.60) | ROCK2ROCK1NPC1RAB9A | |
| SCHEMBL5409293 | 0.64 | ROCK2 (0.67) | ROCK2POLBMEN1KMT2AROCK1 | |
| SCHEMBL18196422 | 0.63 | MKNK1 (0.53) | ROCK2MEN1KMT2AROCK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107835814-B | Azabenzimidazoles and their use as AMPA receptor modulators | 詹森药业有限公司 | 2021-07-23 | — | — | CN | disclosed |