Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18188414 | 0.76 | NPC1 (0.52) | ROCK2ROCK1DYRK3JAK2PRKD3 | |
| SCHEMBL30272857 | 0.76 | SYK (0.46) | SYKMKNK1ULK1ROCK2ROCK1 | |
| SCHEMBL29542975 | 0.75 | MKNK1 (0.53) | MKNK1KDRULK1ROCK2ROCK1 | |
| SCHEMBL18188436 | 0.75 | MKNK1 (0.53) | MKNK1KDRULK1ROCK2ROCK1 | |
| SCHEMBL18188218 | 0.70 | ROCK2 (0.46) | SYKMKNK1ROCK2ROCK1DYRK3 | |
| SCHEMBL18188230 | 0.70 | NPC1 (0.43) | MKNK1ULK1ROCK2ROCK1DYRK3 | |
| SCHEMBL2729193 | 0.69 | SYK (0.59) | SYKJAK3IRAK4MKNK1ROCK2 | |
| SCHEMBL30627079 | 0.69 | TRPA1 (0.53) | DYRK3LCKCLK2GSK3BCDK5 | |
| SCHEMBL28597254 | 0.69 | ROCK2 (0.43) | MKNK1ULK1ROCK2ROCK1RET | |
| SCHEMBL10242647 | 0.69 | SYK (0.67) | SYKJAK3IRAK4KDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4144736-A1 | AZABENZIMIDAZOLES AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |