Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28607435 | 0.91 | PDE3B (0.46) | EIF2AK2EPHX2SRCPDE3BPDE3A | |
| SCHEMBL29016211 | 0.82 | CRBN (0.53) | EIF2AK2CRBNTDP2CMA1AHR | |
| SCHEMBL153506 | 0.81 | EIF2AK2 (0.74) | EIF2AK2EPHX2SRCPDE3BPDE3A | |
| SCHEMBL29016221 | 0.76 | AHR (0.47) | EPHX2PDE3BPDE3ACRBNTDP2 | |
| SCHEMBL3155781 | 0.71 | EIF2AK2 (0.68) | EIF2AK2EPHX2SRCPDE3BPDE3A | |
| SCHEMBL4019289 | 0.71 | EIF2AK2 (0.63) | EIF2AK2EPHX2SRCPDE3BPDE3A | |
| SCHEMBL3151429 | 0.71 | EIF2AK2 (0.62) | EIF2AK2EPHX2SRCPDE3BPDE3A | |
| SCHEMBL29853437 | 0.70 | PDE3B (0.59) | EIF2AK2SRCPDE3BPDE3AALDH1A1 | |
| SCHEMBL26767523 | 0.70 | PDE3B (0.59) | EIF2AK2SRCPDE3BPDE3AALDH1A1 | |
| SCHEMBL1044787 | 0.70 | NOTUM (0.41) | ALDH1A1KDM4EHPGDHSD17B10GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113181362-B | Medicament for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2023-06-13 | — | — | CN | disclosed |
| CN-113181362-A | Agent for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2021-07-30 | — | — | CN | disclosed |