Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28597906 | 0.91 | EIF2AK2 (0.50) | PDE3BPDE3ASRCRETKDM4E | |
| SCHEMBL29016221 | 0.83 | AHR (0.47) | PDE3BPDE3AGAAGRIA1CACNG8 | |
| SCHEMBL31040124 | 0.81 | PDE3B (0.66) | PDE3BPDE3ASRCGAAGRIA1 | |
| SCHEMBL20214 | 0.81 | PDE3B (0.66) | PDE3BPDE3ASRCGAAGRIA1 | |
| Trifluoroacetic Acid SCHEMBL29921460 | 0.78 | PDE3B (0.52) | PDE3BPDE3ASRCGAAMAOB | |
| SCHEMBL3285782 | 0.76 | NPC1 (0.59) | PDE3BPDE3ASRCGAAGRIA1 | |
| SCHEMBL29016211 | 0.75 | CRBN (0.53) | GRIA1CACNG8AHRCRBNEIF2AK2 | |
| SCHEMBL6981292 | 0.71 | AHR (0.51) | PDE3BPDE3AGAAGRIA1CACNG8 | |
| SCHEMBL155069 | 0.71 | PDE3B (0.62) | PDE3BPDE3ASRCGAAGRIA1 | |
| SCHEMBL11469106 | 0.71 | GAA (0.50) | PDE3BPDE3AGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113181362-B | Medicament for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2023-06-13 | — | — | CN | disclosed |
| CN-113181362-A | Agent for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2021-07-30 | — | — | CN | disclosed |